Evidence map›Paper›PMID 42725774›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

TRAIP Mediates Alcohol-Induced Liver Injury through Regulating β-catenin Ubiquitin Degradation via Direct Interaction.

Zhan Wu, Mingjiang Liu, Lijuan Liao, Zhaohong Mo, Wenli Xu, Linfeng Mao, Yubing Chen, Qiuli Xie, Ming Yao, Shilian Chen and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zhan Wu *Division of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Mingjiang Liu *Division of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Lijuan Liao *Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, Ministry of Education, Guangxi Medical University, Nanning, Guangxi, China.
Zhaohong MoDivision of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Wenli XuKey Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, Ministry of Education, Guangxi Medical University, Nanning, Guangxi, China.
Linfeng MaoDivision of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Yubing ChenDivision of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Qiuli XieDivision of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Ming YaoKey Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, Ministry of Education, Guangxi Medical University, Nanning, Guangxi, China.
Shilian ChenKey Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, Ministry of Education, Guangxi Medical University, Nanning, Guangxi, China.
Stephen TomlinsonDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, United States.
Sebastian MuellerCenter for Alcohol Research, University Hospital Heidelberg, Heidelberg, Germany.
Songqing HeDivision of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Guandou YuanDivision of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.ORCID https://orcid.org/0000-0002-4758-1928

Funding

111 Center D17011National Key Research and Development Program of China 2022YFE0131600National Natural Science Foundation of China 82160500National Natural Science Foundation of China 82560123Natural Science Foundation of Guangxi 2025GXNSFAA069121
6 · The paper itself

Abstract

Oxidative stress is a critical driver in the pathogenesis of alcohol-related liver disease (ALD), promoting hepatic inflammation and injury. This study investigates the role of tumor necrosis factor receptor-associated factor interacting protein (TRAIP) in ALD. We utilize in vivo ALD models with liver-specific TRAIP overexpression (LSO) or knockout (LKO) mice. Chromatin immunoprecipitation and luciferase reporter assays confirm NF-κB1 binding to the TRAIP promoter. In vitro, co-immunoprecipitation and domain mapping with truncated mutants identify the interaction between the TRAIP coiled-coil domain and the β-catenin Armadillo domain. TRAIP is significantly upregulated in human and murine ALD tissues. Ethanol-fed TRAIP

Indexed as

alcohol‐related liver diseasefatty liver diseaseNIAAAoxidative stressTRAIP

Identifiers

PMID42725774
PMCPMC13564194

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.