Evidence map›Paper›PMID 42725745›Full record

ArticleMicrobiology spectrum2026

Accounting for serotypic heterogeneity improves the interpretation of pneumococcal vaccine response using serotype-specific ELISA IgG concentrations.

Gatien Durand, Camillia Belhoul, Merieme Bensalah, Maxime Jeljeli, Laurie Toullec, Marine Gil, Elodie Lachiche, Camille Baron, Claire Goulvestre, Christian Drouet and 2 more

Abstract read
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In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Gatien DurandUniversité Paris Cité, Faculté de Médecine, AP-HP-Centre Université de Paris, Hôpital Cochin, Service d'immunologie biologique, Paris, France.ORCID 0009-0007-9456-0779
Camillia BelhoulUniversité Paris Cité, Faculté de Médecine, AP-HP-Centre Université de Paris, Hôpital Cochin, Service d'immunologie biologique, Paris, France.
Merieme BensalahUniversité Paris Cité, Faculté de Médecine, AP-HP-Centre Université de Paris, Hôpital Cochin, Service d'immunologie biologique, Paris, France.
Maxime JeljeliUniversité Paris Cité, Faculté de Médecine, AP-HP-Centre Université de Paris, Hôpital Cochin, Service d'immunologie biologique, Paris, France.
Laurie ToullecUniversité Paris Cité, Faculté de Médecine, AP-HP-Centre Université de Paris, Hôpital Cochin, Service d'immunologie biologique, Paris, France.
Marine GilUniversité Paris Cité, Faculté de Médecine, AP-HP-Centre Université de Paris, Hôpital Cochin, Service d'immunologie biologique, Paris, France.
Elodie LachicheUniversité Paris Cité, Faculté de Médecine, AP-HP-Centre Université de Paris, Hôpital Cochin, Service d'immunologie biologique, Paris, France.
Camille BaronUniversité Paris Cité, Faculté de Médecine, AP-HP-Centre Université de Paris, Hôpital Cochin, Service d'immunologie biologique, Paris, France.
Claire GoulvestreUniversité Paris Cité, Faculté de Médecine, AP-HP-Centre Université de Paris, Hôpital Cochin, Service d'immunologie biologique, Paris, France.
Christian DrouetUniversité Paris Cité, Faculté de Médecine, AP-HP-Centre Université de Paris, Hôpital Cochin, Service d'immunologie biologique, Paris, France.
Frédéric BatteuxUniversité Paris Cité, Faculté de Médecine, AP-HP-Centre Université de Paris, Hôpital Cochin, Service d'immunologie biologique, Paris, France.
Lucie ChevrierUniversité Paris Cité, Faculté de Médecine, AP-HP-Centre Université de Paris, Hôpital Cochin, Service d'immunologie biologique, Paris, France.ORCID 0009-0000-8114-0002

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Assessment of pneumococcal vaccine response by enzyme-linked immunosorbent assay (ELISA) currently relies on a single IgG concentration threshold applied to all serotypes. This approach does not account for the marked serotype variability in the relationship between IgG concentration and functional antibody activity. We investigated whether accounting for serotypic heterogeneity improves the interpretation of pneumococcal vaccine response by establishing serotype-specific IgG concentrations predictive of a positive OPA response (PIC). We analyzed 729 samples from adults referred for assessment of pneumococcal vaccine response. For seven vaccine serotypes, IgG concentrations were measured by ELISA and functional activity of antibodies was assessed by opsonophagocytic assay (OPA). IgG concentrations differed significantly according to both serotype and OPA status. Quantitative analyses demonstrated significant correlations between IgG concentrations and OPA titers for all serotypes (Spearman's ρ = 0.45-0.76; all

Indexed as

Antibodies, BacterialImmunoglobulin GPneumococcal InfectionsPneumococcal VaccinesStreptococcus pneumoniaeAdultAgedEnzyme-Linked Immunosorbent AssayFemaleHumansMaleMiddle AgedPhagocytosisROC CurveSerogroupSerotypingAntibodies, BacterialImmunoglobulin GPneumococcal VaccinesELISAheterogeneityOPApneumococcal vaccineserotypes

Identifiers

PMID42725745
PMCPMC13689387

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.