Evidence map›Paper›PMID 42725679›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026

Identification of Sodium/Myo-Inositol Transporter 1 as a Major Determinant of Arterial Contractility.

Elizabeth A Forrester, Skye Lau, Miguel Benitez-Angeles, Christopher J Garland, Vincenzo Barrese, Anthony P Albert, Iain A Greenwood

Abstract read
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In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elizabeth A ForresterSchool of Health and Medical Sciences, City St George's, University of London, London, UK.ORCID https://orcid.org/0000-0002-2164-103X
Skye LauSchool of Health and Medical Sciences, City St George's, University of London, London, UK.
Miguel Benitez-AngelesSchool of Health and Medical Sciences, City St George's, University of London, London, UK.
Christopher J GarlandDepartment of Pharmacology, University of Oxford, Oxford, UK.
Vincenzo BarreseDeptartment of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy.
Anthony P AlbertSchool of Health and Medical Sciences, City St George's, University of London, London, UK.
Iain A GreenwoodSchool of Health and Medical Sciences, City St George's, University of London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As the sodium/myo-inositol transporter (SMIT1) is a positive regulator of Kv7.4/7.5 channels in arterial smooth muscle, we postulated that altering SMIT1 expression could have a major impact upon vascular reactivity. Consequently, this study aimed to characterize the effects of changes of SMIT1 membrane abundance on vascular tone in 2nd order mesenteric arteries and left anterior coronary arteries from WistarHan rats and identify the molecular mechanisms involved. Morpholino-mediated knockdown of SMIT1 enhanced U46619- and methoxamine-mediated contractions of mesenteric artery while impairing relaxations to the Kv7 activator ML213, isoprenaline and Calcitonin Gene Related Peptide (CGRP). Conversely, augmenting SMIT1 membrane abundance by raising external osmolarity with 150 mM raffinose impaired receptor-mediated contractions of mesenteric and coronary arteries, hyperpolarized the membrane potential and augmented relaxations to ML213 and adenosine. 1 h incubation in raffinose increased heterologously expressed Kv7.4-generated K

Indexed as

Coronary VesselsMesenteric ArteriesMuscle ContractionMuscle, Smooth, VascularSymportersVasoconstrictionAnimalsKCNQ Potassium ChannelsMaleRatsRats, WistarKCNQ Potassium Channelssodium-myo-inositol cotransporter, ratSymportersarterial contractilityblood pressure regulationmembrane hyperpolarizationpotassium channelssodium/myo‐inositol transporter (SMIT1)vascular smooth muscle

Identifiers

PMID42725679
PMCPMC13564097

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.