ArticlePharmaceutical biology2026
Chemical standardization of kava (
Article in Pharmaceutical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
Funding
Abstract
backgroundKava (
objectiveTo support safety studies being carried out by the Botanical Safety Consortium, the chemical profile of a botanically authenticated kava extract was obtained using ultrahigh-pressure liquid chromatography-high resolution tandem mass spectrometry (UHPLC-HRMS/MS), and kavalactones and flavokavains were identified by comparison with standards. MATERIALS AND
methodsThe kava extract was chemically standardized using two analytical methods based on UHPLC-MS/MS with selected reaction monitoring on a triple quadrupole mass spectrometer. One method used external calibration with standards dissolved in neat solvent due to the absence of blank kava matrix, while the second used the method of standard addition to evaluate kava extract matrix effects that might affect the accuracy of the external calibration method.
resultsMatrix-induced ion suppression was observed for desmethoxyyangonin (23.2%) while signal enhancement was observed for 7,8-dihydrokavain (30.1%) and flavokavain A (43.2%). DISCUSSION AND
conclusionsThe method of standard addition is ideal for correcting for botanical matrix effects that can interfere with quantitative assays based on electrospray (U)HPLC-MS/MS. Chemical authentication and standardization are essential for quality control of kava dietary supplements and to support research on their safety and efficacy.
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