Evidence map›Paper›PMID 42725445›Full record

ReviewNatural product reports2026

Accelerating natural product discovery, characterization and engineering by biofoundries.

Ling Hu, Yuwei Pan, Huimin Zhao

Abstract readReview
In one paragraph

Review in Natural product reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ling HuDepartment of Chemical and Biomolecular Engineering, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA. zhao5@illinois.edu.
Yuwei PanCarl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.ORCID http://orcid.org/0009-0009-7278-5840
Huimin ZhaoDepartment of Chemical and Biomolecular Engineering, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA. zhao5@illinois.edu.ORCID http://orcid.org/0000-0002-9069-6739

Funding

A Scalable Platform to Discover Antimicrobials of Ribosomal OriginR01AI144967 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Douglas Alan Mitchell, WILFRED A. VAN DER DONK · 2019 to 2026
$6.0M
NIAID NIH HHS R01 AI144967
6 · The paper itself

Abstract

Covering: From early developments to the presentNatural product (NP) discovery is increasingly constrained by low-throughput screening, repeated rediscovery, and challenges in scaling genome mining-guided validation workflows. This highlight examines how automated biofoundries are accelerating NP discovery, characterization, and engineering through integrated design-build-test-learn (DBTL) cycles. We discuss recent advances in phenotype-first and genome-first discovery strategies enabled by robotics, high-throughput pathway reconstitution, and automated screening platforms. We further highlight emerging technologies, including cell-free biosynthesis, automated culturomics, programmable chassis engineering, and AI-assisted workflow orchestration, that may enable increasingly autonomous biofoundries for scalable exploration of NP chemical space and therapeutic discovery.

Identifiers

PMID42725445
PMCPMC13563438

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.