ArticleMolecular medicine reports2026
KIF4A drives esophageal squamous cell carcinoma via Wnt/β‑catenin signaling and predicts poor prognosis.
Article in Molecular medicine reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Esophageal squamous cell carcinoma (ESCC) accounts for >90% of esophageal cancer cases in China, with a 5‑year overall survival rate of <30% for advanced disease. Kinesin family member 4A (KIF4A) is implicated in multiple malignancies; however, its functional mechanisms in ESCC remain incompletely elucidated. The present study investigated the prognostic value and tumor‑promoting mechanism of KIF4A in ESCC. KIF4A expression was detected in 43 paired ESCC and adjacent non‑malignant tissues, as well as in ESCC cell lines. Loss‑ and gain‑of‑function assays were performed to evaluate the effects of KIF4A on ESCC cell proliferation, migration and tumorigenesis
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