ReviewCureus2026
Mechanistic Insights Into Acute Kidney Injury Complicating Invasive Pulmonary Aspergillosis in Adults.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Invasive pulmonary aspergillosis (IPA) is a life-threatening fungal infection predominantly affecting immunocompromised patients, with a rising incidence observed in atypical hosts such as critically ill individuals. Acute kidney injury (AKI) represents a severe and frequent complication of IPA, markedly increasing morbidity and mortality rates. Despite its clinical significance, the pathophysiological mechanisms underlying IPA-associated AKI remain incompletely understood. This review provides a comprehensive examination of the multifactorial processes contributing to AKI in the context of IPA, including the direct nephrotoxic effects of fungal toxins, dysregulated host immune and inflammatory responses, drug-induced renal toxicity, and hemodynamic disturbances. By integrating recent advances from molecular biology, immunology, and clinical studies, we aim to elucidate the complex interplay of factors driving renal impairment in IPA patients. Understanding these mechanisms is crucial for the development of early diagnostic markers and targeted therapeutic strategies to improve patient outcomes. This comprehensive overview provides a theoretical foundation for future research and clinical management of IPA complicated by AKI.
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