Evidence map›Paper›PMID 42725327›Full record

ArticleCureus2026

A Case of Statin-Induced Fulminant Hepatitis Presenting as Septic Shock and Multiorgan Failure.

Matthew E Lehrack, John Daliva, Nadir E Eltahir, Ronald Chang, Aftab Qadir

Abstract readCase Reports
In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Matthew E LehrackInternal Medicine, Western University of Health Sciences, Pomona, USA.
John DalivaInternal Medicine, Pomona Valley Hospital Medical Center, Pomona, USA.
Nadir E EltahirIntensive Care Medicine, Pomona Valley Hospital Medical Center, Pomona, USA.
Ronald ChangInternal Medicine, Pomona Valley Hospital Medical Center, Pomona, USA.
Aftab QadirIntensive Care Medicine, Pomona Valley Hospital Medical Center, Pomona, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Statins are among the most widely prescribed medications for hyperlipidemia, with drug-induced liver injury (DILI) being a rare adverse event. Here, we report a case involving a 69-year-old female patient who developed fulminant liver failure following an overdose of rosuvastatin. The patient had ingested 60 tablets of rosuvastatin 20 mg over the one-week period prior to hospital admission, mistakenly believing it was her pain medication. This acute high-dose exposure far exceeded recommended dosing and resulted in fulminant hepatitis and multiorgan failure. Despite comprehensive critical care, including advanced supportive and rescue interventions, the patient's condition deteriorated, and she did not survive. This underscores the potential lethality of statin overdose and the importance of medication safety, early recognition, and prevention strategies.

Indexed as

statin-induced liver necrosisstatin overdosestatin safetystatin side effectsstatin toxicity

Identifiers

PMID42725327
PMCPMC13561578

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.