ArticleIndian journal of psychiatry2026
Unmasking the invisible: Proteomic traces of depression in human serum - A pilot study.
Article in Indian journal of psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Depression is a major cause of reduced productivity and increased morbidity. Aim: Given its complex and multifactorial pathophysiology, this study investigated serum proteomic profiles in individuals with depression and healthy controls to identify differentially expressed proteins and their functional significance. Methods: This is a cross-sectional observational study. Individuals with depression ( Result: In our main finding of the liquid chromatography-tandem mass spectrometry (LC-MS/MS) study of serum samples, a total of 242 proteins were identified, out of that 9 were upregulated and 11 were downregulated in the serum from the depression group and in the healthy control group. Receiver operating characteristic (ROC) analysis of significantly altered proteins showed strong discriminatory ability for fibrinogen, Conclusion: This study identifies a distinct molecular signature of depression, with
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