ArticleTransplantation direct2026
Association Between Donor HLA-DQ Heterodimers Group and Graft Loss in Kidney Transplant Recipients.
Article in Transplantation direct, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
7 authors.
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Abstract
Background: Combinations of HLA-DQ α1 and β1 chains are restricted to specific groups: group 1 (G1), comprising DQA1*02/03/04/05/06 with DQB1*02/03/04, and group 2 (G2), comprising DQA1*01 with DQB1*05/06. A recently discovered role of HLA-DQ heterodimers in hematopoietic cell transplantation suggests poorer outcomes in patients carrying G2 heterodimers. However, the absence of a clear biological rationale has raised questions regarding the generalizability of this observation. Methods: To further evaluate this finding, we investigated the impact of the HLA-DQ group genotype in 821 kidney recipients by multivariate survival modeling. Results: Compared with recipients of G1G1 donor grafts, those who received G2G2 donor grafts had a 1.9-fold (95% confidence interval [CI], 1.2-2.9; Conclusions: The paradigm based on HLA-DQ heterodimers appears to be shared between hematopoietic and solid organ transplantation, strongly encouraging investigation into the underlying biological mechanisms.
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