Evidence map›Paper›PMID 42725251›Full record

ArticleAnnals of medicine and surgery (2012)2026

WATCHMAN and Amplatzer Amulet for left atrial appendage occlusion: a systematic review and meta-analysis.

Samir Maher Shamieh, Barakat Wael Alsaqqa, Armstrong Nicholas Kpachi, Mohamed Kamal Said, Krishnanjali Kishore, Jui Kanetkar, Iqra Tariq, Muskan Shrestha, Nima Rasti, Deng Siang Lee and 4 more

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Article in Annals of medicine and surgery (2012), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Samir Maher ShamiehFaculty of Medicine, University of Jordan, Amman, Jordan.ORCID https://orcid.org/0009-0004-5494-3765
Barakat Wael AlsaqqaFaculty of Medicine, University of Jordan, Amman, Jordan.
Armstrong Nicholas KpachiDepartment of Medicine, Kings College Hospital, London, UK.
Mohamed Kamal SaidFaculty of Medicine, Mansoura University, Mansoura, Egypt.
Krishnanjali KishoreDepartment of Medicine, Kannur Medical College, Kannur, India.
Jui KanetkarFaculty of Medicine and Health Sciences, University of Buckingham Medical School, Buckingham, UK.
Iqra TariqDepartment of Medicine, Allied Hospital II Faisalabad, Faisalabad, Pakistan.
Muskan ShresthaDepartment of Medicine, Tribhuwan University, Kathmandu, Nepal.
Nima RastiSchool of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
Deng Siang LeeFaculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain.
Roya LalzaiFaculty of Medicine, Kabul Medical University, Kabul, Afghanistan.
Ashesh DasDepartment of Medicine, KPC Medical College and Hospital, Kolkata, India.
Malik Sohail RiazDepartment of Medicine, International University of Kyrgyzstan, Bishkek, Kyrgyzstan.ORCID https://orcid.org/0009-0006-4406-1691
Muneeb KhawarDepartment of Medicine, King Edward Medical University, Lahore, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: WATCHMAN and Amplatzer Amulet devices are an effective alternative to oral anticoagulation for left atrial appendage closure (LAAC) in non-valvular atrial fibrillation (NVAF) patients. This study aims to compare their safety and efficacy. Methods: This systematic review and meta-analysis followed PRISMA guidelines. PubMed, Embase, and ScienceDirect, were searched from inception to May 2025 for comparative studies in NVAF patients. Pooled risk ratios (RRs) with 95% confidence intervals (CIs) were calculated using random-effects models. Heterogeneity was assessed via Results: Sixteen studies were included. No significant differences were found in ischemic stroke (RR 1.10, 95% CI 0.83-1.46; Conclusions: WATCHMAN and Amulet demonstrate no significant difference in efficacy and safety for most LAAC outcomes, including stroke and major bleeding. However, WATCHMAN is associated with a significantly lower risk of pericardial effusion but a higher risk of device thrombosis.

Indexed as

Amplatzer Amuletatrial fibrillationleft atrial appendage closurestroke preventionWATCHMAN

Identifiers

PMID42725251
PMCPMC13561207

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.