ArticleACG case reports journal2026
Incidentally Diagnosed Very Well-Differentiated Gastric Adenocarcinoma at Intraoperative Frozen Section.
Article in ACG case reports journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Very well-differentiated gastric adenocarcinoma is a rare subtype that is often overlooked because of minimal cytological atypia and ill-defined gross findings. We report an 82-year-old man who was incidentally diagnosed with this entity in an intraoperative cut-end frozen section during gastrectomy for another adenocarcinoma. The frozen specimen showed irregularly fused glands with characteristic architecture, prompting additional resection to secure negative margins. Immunohistochemistry revealed loss of AT-rich interaction domain 1A expression exclusively in the neoplastic glands. This case highlights the importance of recognizing subtle architectural abnormalities in frozen sections to avoid overlooking clinically undetected gastric neoplasms.
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