Evidence map›Paper›PMID 42725083›Full record

ArticleMaterials today. Bio2026

A targeted triple-action redox-modulating hydrogel potentiates fibroblast-mediated repair to accelerate oral wound healing.

Xiheng Li, Shizhuo Miao, Chunru Kong, Wenjie Ma, Wanqi Yang, Yuandong Xie, Xiaomeng Wang, Xiaoduo Tang, Junhu Zhang, Bei Chang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiheng LiJilin Provincial Key Laboratory of Oral and Craniofacial Diseases & Tissue Reconstruction, Hospital of Stomatology, Jilin University, Changchun, 130021, China.
Shizhuo MiaoState Key Laboratory of Supramolecular Structure and Material, Center for Supramolecular Chemical Biology, College of Chemistry, Jilin University, Changchun, 130012, China.
Chunru KongJilin Provincial Key Laboratory of Oral and Craniofacial Diseases & Tissue Reconstruction, Hospital of Stomatology, Jilin University, Changchun, 130021, China.
Wenjie MaJilin Provincial Key Laboratory of Oral and Craniofacial Diseases & Tissue Reconstruction, Hospital of Stomatology, Jilin University, Changchun, 130021, China.
Wanqi YangJilin Provincial Key Laboratory of Oral and Craniofacial Diseases & Tissue Reconstruction, Hospital of Stomatology, Jilin University, Changchun, 130021, China.
Yuandong XieJilin Provincial Key Laboratory of Oral and Craniofacial Diseases & Tissue Reconstruction, Hospital of Stomatology, Jilin University, Changchun, 130021, China.
Xiaomeng WangJilin Provincial Key Laboratory of Oral and Craniofacial Diseases & Tissue Reconstruction, Hospital of Stomatology, Jilin University, Changchun, 130021, China.
Xiaoduo TangDepartment of Hand and Podiatric Surgery, Orthopedics Center, The First Hospital of Jilin University, Jilin University, Changchun, 130031, China.
Junhu ZhangState Key Laboratory of Supramolecular Structure and Material, Center for Supramolecular Chemical Biology, College of Chemistry, Jilin University, Changchun, 130012, China.
Bei ChangJilin Provincial Key Laboratory of Oral and Craniofacial Diseases & Tissue Reconstruction, Hospital of Stomatology, Jilin University, Changchun, 130021, China.
Hongchen SunJilin Provincial Key Laboratory of Oral and Craniofacial Diseases & Tissue Reconstruction, Hospital of Stomatology, Jilin University, Changchun, 130021, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral mucosal defects cause persistent pain and impair essential orofacial functions, making rapid healing a clinical priority. However, the specific microenvironmental factors that limit mucosal repair are not fully characterized. Using single-cell transcriptomic profiling, we identified oxidative stress-mediated inhibition of fibroblast extracellular matrix (ECM) synthesis as a critical barrier to wound healing. To address this, we developed an injectable hydrogel (FA/Zn-KR/Gel) that incorporates ferulic acid (FA) and a Zn

Indexed as

Antimicrobial peptideExtracellular matrixInjectable hydrogelOral wound healingOxidative stress

Identifiers

PMID42725083
PMCPMC13560323

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.