Evidence map›Paper›PMID 42724964›Full record

ArticleResuscitation plus2026

Neurofilament light chain for assessment of brain injury in four porcine cardiac arrest models.

Olof Persson, Attila Frigyesi, Anna Valerianova, Mikuláš Mlček, Renaud Tissier, Fanny Lidouren, Matthias Kohlhauer, Giuseppe Ristagno, Aurora Magliocca, Francesca Fumagalli and 7 more

Abstract read
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In one paragraph

Article in Resuscitation plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Olof PerssonDepartment of Clinical Sciences, Anesthesiology and Intensive Care, Lund University, Lund, Sweden.
Attila FrigyesiDepartment of Clinical Sciences, Anesthesiology and Intensive Care, Lund University, Lund, Sweden.
Anna ValerianovaInstitute of Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Mikuláš MlčekInstitute of Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Renaud TissierEcole nationale vétérinaire d'Alfort, IMRB, Inserm U955, After ROSC Network, Maisons-Alfort, France.
Fanny LidourenEcole nationale vétérinaire d'Alfort, IMRB, Inserm U955, After ROSC Network, Maisons-Alfort, France.
Matthias KohlhauerEcole nationale vétérinaire d'Alfort, IMRB, Inserm U955, After ROSC Network, Maisons-Alfort, France.
Giuseppe RistagnoDepartment of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
Aurora MaglioccaDepartment of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
Francesca FumagalliDepartment of Cardiovascular Medicine, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
Kaj BlennowDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Mohamad Hakam TibaDepartment of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA.
Cindy H HsuDepartment of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA.
Thomas H SandersonDepartment of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA.
Robert NeumarDepartment of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA.
Hans FribergDepartment of Clinical Sciences, Anesthesiology and Intensive Care, Lund University, Lund, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Anoxic brain injury is the leading cause of death following successful resuscitation after out-of-hospital cardiac arrest. No experimental neuroprotective therapy has translated into clinical benefit. Collaborative efforts to harmonize methods may be essential for translational success. Neurofilament light chain (NfL) is a biomarker of neuroaxonal injury with emerging use in clinical practice, but data on its robustness and association with outcomes in porcine models is limited. Our aim was to use NfL as a quantitative marker to compare brain injury severity in different porcine cardiac arrest models. Methods: Forty-four pigs ( Results: NfL levels changed significantly over time ( Conclusion: NfL increased consistently across four porcine cardiac arrest models, and higher 24-h NfL levels were associated with longer no-flow duration, supporting its robustness as a biomarker of neuroaxonal injury. Larger studies are needed to clarify its relationship with functional outcome, as the exploratory analyses were underpowered.

Indexed as

Cardiac arrestFunctional outcomeNeurofilament light chain (NfL)PorcineSwine

Identifiers

PMID42724964
PMCPMC13559832

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.