ArticleTranslational cancer research2026
miR-27b-5p targets RAB27A to regulate exosome secretion and migration of pancreatic cancer cells.
Article in Translational cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Exosomes are the key mediators of intercellular communication within the tumor microenvironment. Pancreatic cancer (PC) exhibits an abnormal increase in exosome secretion, and this abnormal secretion is closely associated with the invasive migration and metastatic progression of PC. Although the role of exosomes in PC metastasis has been confirmed, the precise molecular mechanism regulating this process remains unclear. This study aims to explore the regulatory mechanism of the exosome secretion cascade and its correlation with malignant migration in PC. Methods: By comparing the serum miRNA profiles of PC patients with those of healthy controls, the key inhibitory factor microRNA-27b-5p (miR-27b-5p) was identified. After verifying its direct targeting of RAB27A, overexpression of miR-27b-5p and RAB27A rescue experiments were conducted in PC cells. Combined with the detection of intracellular multivesicular bodies (MVBs), the mechanism by which this axis regulates exosome secretion and PC metastasis was explored. Results: Conclusions: This study reveals a novel molecular mechanism: miR-27b-5p directly targets RAB27A to suppress PC cell migration. This regulatory axis may contribute to exosome-related metastatic phenotypes of PC.
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