Evidence map›Paper›PMID 42724751›Full record

ArticleMolecular therapy. Nucleic acids2026

Hong Liu, Shuren Liao, Chen Chen, Wenwen Huo, Zahra Safaei, Angela Rocchi, Yuru Huang, Ilker K Sariyer, Mackenzie E Collins, Jill M Lawrence and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Hong LiuCenter for Neurovirology and Gene Editing, Department of Microbiology, Immunology and Inflammation, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, 7th Floor, Philadelphia, PA 19140, USA.
Shuren LiaoCenter for Neurovirology and Gene Editing, Department of Microbiology, Immunology and Inflammation, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, 7th Floor, Philadelphia, PA 19140, USA.
Chen ChenCenter for Neurovirology and Gene Editing, Department of Microbiology, Immunology and Inflammation, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, 7th Floor, Philadelphia, PA 19140, USA.
Wenwen HuoExcision BioTherapeutics, Inc., 499 Jackson Street, San Francisco, CA 94111, USA.
Zahra SafaeiCenter for Neurovirology and Gene Editing, Department of Microbiology, Immunology and Inflammation, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, 7th Floor, Philadelphia, PA 19140, USA.
Angela RocchiCenter for Neurovirology and Gene Editing, Department of Microbiology, Immunology and Inflammation, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, 7th Floor, Philadelphia, PA 19140, USA.
Yuru HuangCenter for Neurovirology and Gene Editing, Department of Microbiology, Immunology and Inflammation, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, 7th Floor, Philadelphia, PA 19140, USA.
Ilker K SariyerCenter for Neurovirology and Gene Editing, Department of Microbiology, Immunology and Inflammation, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, 7th Floor, Philadelphia, PA 19140, USA.
Mackenzie E CollinsCenter for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 W Queen Ln, Philadelphia, PA 19129, USA.
Jill M LawrenceCenter for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 W Queen Ln, Philadelphia, PA 19129, USA.
Will DampierCenter for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 W Queen Ln, Philadelphia, PA 19129, USA.
Michael R NonnemacherCenter for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 W Queen Ln, Philadelphia, PA 19129, USA.
Brian WigdahlCenter for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 W Queen Ln, Philadelphia, PA 19129, USA.
Tricia H BurdoRutgers Institute for Translational Medicine and Science, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, 89 French Street, Suite 4275, New Brunswick, NJ 08901, USA.
Jennifer GordonExcision BioTherapeutics, Inc., 499 Jackson Street, San Francisco, CA 94111, USA.
Mark LewisBioqual, Inc., 9600 Medical Center Drive, #101, Rockville, MD 20850, USA.
Cheri A LeeBioqual, Inc., 9600 Medical Center Drive, #101, Rockville, MD 20850, USA.
Kamel KhaliliCenter for Neurovirology and Gene Editing, Department of Microbiology, Immunology and Inflammation, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, 7th Floor, Philadelphia, PA 19140, USA.

Funding

CRISPR for CureUM1AI164568 · NIAID · TEMPLE UNIV OF THE COMMONWEALTH · PI Tricia Helen Burdo, Kamel Khalili · 2021 to 2026
$27.7M
Viral Gene Editing and Bioinformatics Core for Institution # 269291P30MH092177 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI Ilker Kudret Sariyer · 2011 to 2026
$24.9M
NIAID NIH HHS UM1 AI164568NIMH NIH HHS P30 MH092177
6 · The paper itself

Abstract

Latent human immunodeficiency virus type 1 (HIV-1) reservoirs in the central nervous system (CNS) may sustain viral persistence and neuroinflammation contributing to HIV-associated neurocognitive disorders (HAND) despite suppressive ART. AAV9-delivered CRISPR has successfully edited SIV proviral DNA in peripheral tissues with acceptable safety profiles, but the extent of

Indexed as

ARTbrain regionsCNS infectionCRISPR-Cas9excisionHIVMT: RNA/DNA editingSIVviral persistenceviral reservoirs

Identifiers

PMID42724751
PMCPMC13560538

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.