ArticleEuropean journal of case reports in internal medicine2026
Pregnancy Complicated by Systemic Lupus Erythematosus, Autoimmune Hepatitis and Portal Hypertension.
Article in European journal of case reports in internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Pregnancy in women with concurrent systemic lupus erythematosus (SLE), autoimmune hepatitis and portal hypertension is exceptionally rare, with fewer than 10 reported cases of any two conditions together and none describing the full triad with detailed haemostatic assessment. Case description: A 26-year-old woman at 9-10 weeks of gestation presented with abnormal liver enzymes, thrombocytopenia, and later developed subacute cutaneous SLE. Autoimmune evaluation revealed positive anti-double-stranded deoxyribonucleic acid (45 IU/ml), low complement C3 (0.68 g/l), and elevated serum IgG (18.2 g/l) supporting a diagnosis of SLE and probable autoimmune hepatitis. Doppler ultrasound confirmed compensated portal hypertension with splenomegaly. Multidisciplinary management included methylprednisolone, hydroxychloroquine, and low-dose aspirin. The platelet count remained stable (85-105 × 10 Conclusion: Favourable outcomes are achievable despite the concurrent burden of SLE, autoimmune hepatitis (AIH) and portal hypertension in pregnancy. Key points include interpreting thrombocytopenia as a multifactorial sign, balancing bleeding and thrombosis risks, and delivering individualised multidisciplinary care. LEARNING POINTS: Pregnancy in women with concurrent systemic lupus erythematosus (SLE), autoimmune hepatitis and portal hypertension is rare but can achieve favourable maternal and neonatal outcomes with individualized multidisciplinary care.Thrombocytopenia in this setting is often multifactorial (hypersplenism, immune-mediated, pregnancy-related). A stable platelet count above 50 ×10
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