ArticleJournal of thoracic disease2026
Association of resection type, nodal evaluation, and survival in early-stage lung squamous cell carcinoma.
Article in Journal of thoracic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
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Abstract
Background: While recent trials suggest sublobar resection is non-inferior to lobectomy for stage IA non-small cell lung cancer (NSCLC), patients with squamous cell carcinoma (SCC) were underrepresented. We aimed to evaluate outcomes of sublobar resection versus lobectomy in early-stage SCC. Methods: Using the National Cancer Database (NCDB; 2010-2022), we identified patients >18 years with stage IA SCC. We compared demographics, tumor characteristics, perioperative outcomes, nodal evaluation, and survival between patients undergoing lobectomy or sublobar resection. Overall survival was evaluated using Kaplan-Meier analysis and Cox proportional hazards regression, with sequential adjustment for lymph node evaluation to assess its influence on survival estimates. Results: Among 207 patients, 63% underwent lobectomy and 37% sublobar resection. The sublobar group was older (72.0 Conclusions: Although overall survival appeared higher following lobectomy, this association was attenuated after adjustment for lymph node evaluation and was no longer statistically significant. These findings highlight the importance of adequate nodal assessment and should be considered hypothesis-generating.
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