ArticleRSC medicinal chemistry2026
Flavonoids and chalcones as selective α-glucosidase inhibitors: from enzymatic screening to validation using the human enzyme.
Article in RSC medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
α-Glucosidase is a key therapeutic target for postprandial glucose control, but most clinically available inhibitors also inhibit α-amylase, leading to gastrointestinal side effects. Natural polyphenols have been widely reported as potent and selective α-glucosidase inhibitors, primarily based on screening assays using yeast enzyme and synthetic substrates. In this study, thirteen flavonoids and five chalcones were initially evaluated using this conventional approach to elucidate the structural determinants of selective α-glucosidase inhibition. Among them, genistein and myricetin emerged as the most potent inhibitors of yeast α-glucosidase, with IC
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