Evidence map›Paper›PMID 42724604›Full record

ArticleMaterials today. Bio2026

A magnetic nanorobot with guided aggregation and thrombin-triggered coagulation for endovascular embolization.

Jinming Fan, Feile Ye, Jiayuan Lin, Honggang Shi, Yifei Hu, Jincheng Liu, Yajun Yuan, Xianglong Zhong, Yuhan Jiang, Shengchao Zhao and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jinming FanGuangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, 519000, China.
Feile YeGuangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, 519000, China.
Jiayuan LinGuangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, 519000, China.
Honggang ShiGuangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, 519000, China.
Yifei HuGuangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, 519000, China.
Jincheng LiuMechanical Electronics Engineering, Nanjing Forestry University, Nanjing, 210000, China.
Yajun YuanGuangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, 519000, China.
Xianglong ZhongDepartment of Orthopedics, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, 519000, China.
Yuhan JiangDepartment of Orthopedics, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, 519000, China.
Shengchao ZhaoGuangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, 519000, China.
Jinyan GuLibrary, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, 519000, China.
Menghui LiuDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Qing ZhaoDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Ke ZhangGuangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, 519000, China.
Xin PengGuangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, 519000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current endovascular embolic agents face challenges in achieving precise localization and targeted embolization. Herein, we report a novel magnetic nano-embolization robot (MNER) that integrates real-time magnetic aggregation with thrombin-triggered coagulation, enabling a transition from passive diffusion to magnetically controlled focal embolization. The MNER features a core-shell structure with a magnetic core and a thrombin outer layer. Upon endovascular injection, MNER aggregates at the target sites under magnetic guidance, while surface-anchored thrombin triggers fibrin polymerization, promoting the rapid formation of stable blood clotting and localized embolization. The MNER exhibits excellent magnetic response in static and circulating fluid environments in vitro. In rabbit models, the MNER achieved effective and sustained embolization in renal arteries (≈3 mm) without migration or recanalization, and enabled precise occlusion in hemorrhagic mesenteric arteries with complex branches. Owing to its easy usage, biocompatibility, and potent embolization, the MNER represents a promising next-generation platform for endovascular embolization, enabling to achieve precise local retention at the target site via magnetic aggregation in conjunction with catheter-based delivery.

Indexed as

Endovascular embolizationMagnetic aggregationNanorobotStimuli-responsive materialsThrombin-triggered coagulation

Identifiers

PMID42724604
PMCPMC13560331

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.