Evidence map›Paper›PMID 42724446›Full record

ArticleTranslational cancer research2026

PDZ-binding kinase promotes ovarian cancer cell proliferation and invasion via

Guzhanuer Awuti, Jiapo Wang, Yun Lu, Haonan Jiang, Xiaoqing Guo

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Article in Translational cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Guzhanuer Awuti *Department of Gynecology, Kasgar Prefecture Second People's Hospital, Kasgar, China.
Jiapo Wang *Department of Gynecology, Shanghai First Maternity and Infant Hospital, Shanghai, China.
Yun LuDepartment of Gynecology, Shanghai First Maternity and Infant Hospital, Shanghai, China.
Haonan JiangDepartment of Gynecology, Shanghai First Maternity and Infant Hospital, Shanghai, China.
Xiaoqing GuoDepartment of Gynecology, Shanghai First Maternity and Infant Hospital, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ovarian cancer is one of the most lethal gynecological malignancies, characterized by late diagnosis, frequent recurrence, and high mortality. PDZ-binding kinase (PBK), a serine/threonine kinase of the mitogen-activated protein kinase kinase (MAPKK) family, has been implicated in the tumorigenesis of multiple cancers, yet its role in ovarian cancer remains incompletely characterized. This study aimed to investigate the effect of PBK on the proliferation and invasion of ovarian cancer cells. Methods: The expression of Results: PBK was significantly overexpressed in ovarian cancer tissues and cell lines compared with normal controls, and high Conclusions: PBK promotes ovarian cancer cell proliferation and invasion. PBK knockdown leads to

Indexed as

cell invasioncell proliferationcyclin B1 (CCNB1)ovarian cancerPDZ-binding kinase (PBK)

Identifiers

PMID42724446
PMCPMC13559573

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.