Evidence map›Paper›PMID 42724413›Full record

ArticleTranslational pediatrics2026

Development and validation of a risk prediction model for respiratory tract

Jinju Shi, Huiyue Zhang, Yanni Xu, Hongzhu Cai, Shaoru Zheng, Cuimin Su

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Article in Translational pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Jinju ShiDepartment of Neonatology, Jinjiang Municipal Hospital (Shanghai Sixth People's Hospital Fujian), Jinjiang, China.
Huiyue ZhangDepartment of Neonatology, Jinjiang Municipal Hospital (Shanghai Sixth People's Hospital Fujian), Jinjiang, China.
Yanni XuDepartment of Neonatology, Jinjiang Municipal Hospital (Shanghai Sixth People's Hospital Fujian), Jinjiang, China.
Hongzhu CaiDepartment of Neonatology, Jinjiang Municipal Hospital (Shanghai Sixth People's Hospital Fujian), Jinjiang, China.
Shaoru ZhengDepartment of Neonatology, Jinjiang Municipal Hospital (Shanghai Sixth People's Hospital Fujian), Jinjiang, China.
Cuimin SuDepartment of Neonatology, Jinjiang Municipal Hospital (Shanghai Sixth People's Hospital Fujian), Jinjiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Methods: A total of 430 preterm infants admitted to the Department of Neonatology of Jinjiang Municipal Hospital from September 2022 to December 2024 were selected as the research subjects. Polymerase chain reaction (PCR)-fluorescent probe method was used to detect UU-DNA in respiratory secretions within 48 hours after admission. According to the test results, the preterm infants were divided into the UU-positive group (n=92) and the UU-negative group (n=338). Multivariable binary logistic regression analysis was performed to identify independent risk factors for UU infection. R software was used to construct a nomogram prediction model for respiratory UU infection in preterm infants, and the receiver operating characteristic (ROC) curve was used to evaluate the efficacy of the model. Results: Multivariable logistic regression analysis showed that maternal vaginal delivery [odds ratio (OR) =0.07, 95% confidence interval (CI): 0.033-0.149], premature rupture of membranes (OR =6.04, 95% CI: 3.023-12.065), chorioamnionitis (OR =3.498, 95% CI: 1.545-7.921), UU infection of the genital tract (OR =13.949, 95% CI: 6.858-28.373), and white blood cell count in preterm infants (OR =1.11, 95% CI: 1.033-1.192) were independent risk factors for UU infection in preterm infants. The above risk factors were introduced into R software to construct a nomogram model. The area under the ROC curve was 0.931 (95% CI: 0.905-0.956), the sensitivity was 90.2%, and the specificity was 82.8%, which had good prediction efficiency. Conclusions: The nomogram model based on the five independent risk factors of vaginal delivery, premature rupture of membranes, chorioamnionitis, UU infection of the genital tract, and white blood cell count of preterm infants has a high predictive ability. For preterm infants with high-risk factors, UU detection should be performed in time to achieve early diagnosis and intervention, reduce the incidence of serious complications, and improve the prognosis of children.

Indexed as

nomogramprediction modelpreterm infantsrisk factorsUreaplasma urealyticum (UU)

Identifiers

PMID42724413
PMCPMC13559109

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