ArticleTranslational pediatrics2026
Clinical characteristics and prognosis of infant onset inflammatory bowel disease in Chinese children: a 10-year single-center experience.
Article in Translational pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Infant-onset inflammatory bowel disease (IO-IBD) is a rare, severe subtype of pediatric IBD with insufficient clinical and genetic data in northern China. This study aimed to investigate the clinical characteristics, gene mutation spectrum, treatment responses and long-term prognosis of IO-IBD in children in northern China, and to provide evidence-based basis for the standardized diagnosis and treatment of this disease. Methods: A retrospective analysis was conducted on the clinical data of 98 children diagnosed with IO-IBD in Beijing Children's Hospital from January 2016 to December 2025. According to clinical phenotypes, the patients were divided into Crohn's disease (CD) phenotype and ulcerative colitis (UC) phenotype. The clinical features, laboratory examinations, treatment regimens and prognoses were compared between the two groups. Whole-exome sequencing or IBD gene panel testing was performed on 77 children to analyze the differences in clinical characteristics and prognoses between monogenic and non-monogenic IO-IBD. Results: Among the 98 children with IO-IBD, 64 (65.3%) had CD phenotype and 34 (34.7%) had UC phenotype. The median age of onset in the entire cohort was 4 months. There was no significant difference in the median age of onset between CD and UC phenotype children (5.0 Conclusions: IO-IBD in children in northern China is predominantly CD phenotype with a high proportion of monogenic causes, among which
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