ReviewJournal of thoracic disease2026
Role of quantitative ventilation/perfusion scan (qVQ) in the pre-treatment assessment of bronchoscopic lung volume reduction with endobronchial valves (BLVR-EBV) for emphysema and the pre-operative assessment for lung cancer: a systematic review.
Review in Journal of thoracic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: Quantitative ventilation/perfusion scan (qVQ) can assess differential lobar function and can guide management in bronchoscopic lung volume reduction with endobronchial valves (BLVR-EBV) and pre-operative assessment for lung resection for malignancy, but is not universally used clinically. Thus, for both indications we did a systematic review to evaluate qVQ: accuracy; proof of clinical value; and comparison with other imaging modalities. Methods: We started a literature search from August 2025 in 4 databases: CENTRAL, MEDLINE, Embase, Emcare. We followed the PRISMA guidelines and prospectively registered with PROSPERO. The studies were assessed by three reviewers. Results: A total of 1,756 abstracts were reviewed, 164 titles were selected for full text reviews. In total 40 full texts and 5 abstracts were included. We added our 2 recent publications and 2 other citations. For BLVR-EBV we found qVQ: target lobe (TL) choice is concordant with gold standard quantitative computed tomography (qCT); identifies altered lobar physiology post BLVR-EBV favouring the ipsilateral untreated lobe (IUL); has comparable results with quantitative functional CT (qFCT). For lung malignancy we found qVQ: accurately predicts post-operative pulmonary functional outcomes; has comparable results with other imaging modalities; has value in sub lobar resection and in radiotherapy. Conclusions: For BLVR-EBV and lung malignancy assessment, qVQ appears to be accurate; has value in guiding treatment decisions and prognostication; and is at least as accurate as other imaging techniques.
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