Evidence map›Paper›PMID 42724224›Full record

ArticleFrontiers in medicine2026

RBPMS::NTRK3-rearranged sacral malignant spindle cell tumor in neurofibromatosis diagnosed by RNA sequencing: a case report and literature review.

Chaopeng Chen, Bin Qi, Yuanyuan Miao, Zhujiang Zhuang, Chaowen Wang, Weiping Dai

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chaopeng ChenDepartment of Pathology, Central Hospital of Guangdong Provincial Nongken, Zhanjiang, Guangdong, China.
Bin QiDepartment of Pathology, Central Hospital of Guangdong Provincial Nongken, Zhanjiang, Guangdong, China.
Yuanyuan MiaoDepartment of Pathology, Central Hospital of Guangdong Provincial Nongken, Zhanjiang, Guangdong, China.
Zhujiang ZhuangDepartment of Pathology, Central Hospital of Guangdong Provincial Nongken, Zhanjiang, Guangdong, China.
Chaowen WangDepartment of Pathology, Central Hospital of Guangdong Provincial Nongken, Zhanjiang, Guangdong, China.
Weiping DaiDepartment of Pathology, Central Hospital of Guangdong Provincial Nongken, Zhanjiang, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malignant spindle cell tumors arising in patients with neurofibromatosis are diagnostically challenging because malignant peripheral nerve sheath tumor (MPNST) and emerging NTRK-rearranged mesenchymal neoplasms may show overlapping clinical, histological, and immunophenotypic features. We report a 31-year-old man with a more than 20-year history of neurofibromatosis who presented with progressive lumbosacral pain and left lower-limb numbness. Imaging revealed a large cystic-solid sacral mass involving the S1-S2 region and extending through the sacral foramina into the pelvis. Core needle biopsy showed an intermediate-grade malignant spindle cell tumor with partial CD34 expression, strong pan-TRK positivity, increased p53 expression, and a Ki-67 labeling index up to 50% in hotspot areas. NTRK1 break-apart fluorescence

Indexed as

entrectinibmalignant peripheral nerve sheath tumorneurofibromatosisNTRK3NTRK-rearranged spindle cell neoplasmpan-TRKRBPMS::NTRK3 fusionRNA sequencing

Identifiers

PMID42724224
PMCPMC13558397

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.