ArticleNarra J2026
Association of interleukin-6 and C-reactive protein with in-hospital mortality in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention.
Article in Narra J, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Inflammation contributes substantially to the pathogenesis of acute coronary syndromes (ACS), and interleukin-6 (IL-6) and C-reactive protein (CRP) have been proposed as biomarkers of adverse outcomes. The aim of this study was to evaluate the associations of IL-6 and CRP with in-hospital mortality among patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). This prospective cohort study enrolled adult patients with STEMI who underwent primary PCI at Dr. Sardjito General Hospital, Yogyakarta, Indonesia, in 2023. A single blood sample for IL-6 and CRP measurement was collected within 24 hours after PCI. In-hospital mortality was recorded during hospitalization. Receiver operating characteristic analysis identified optimal cut-off values, and multivariable logistic regression was performed to adjust for potential confounders. In-hospital mortality occurred in 6 patients (12.8%). In univariate analysis, higher IL-6 and CRP levels were associated with in-hospital mortality. IL-6 ≥84.60 pg/mL showed an area under the curve (AUC) of 0.776, sensitivity of 66.7%, and specificity of 82.9% (
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