ArticleTranslational pediatrics2026
Clinical outcomes and determinants of intraoperative hyperlactatemia in neonates undergoing gastrointestinal surgery: a retrospective cohort analysis.
Article in Translational pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The clinical significance of hyperlactatemia in neonates undergoing gastrointestinal surgery remains unclear. This study aimed to evaluate the prevalence, clinical outcomes, and associated risk factors of intraoperative hyperlactatemia (IHL) among neonates undergoing gastrointestinal surgery. Methods: A retrospective cohort analysis was conducted, including neonates who underwent gastrointestinal surgical procedures between May 2020 and October 2022. IHL was defined as a blood lactate concentration exceeding 2.0 mmol/L. The incidence of IHL was determined alongside relevant clinical characteristics and postoperative outcomes. Potential risk factors were explored using univariate analysis followed by multivariable logistic regression. Results: Of the 570 neonates included, 34.6% developed IHL. Neonates with IHL demonstrated significantly higher 30-day mortality (15.2% Conclusions: IHL is frequently observed in neonatal gastrointestinal surgery and is strongly associated with adverse clinical outcomes. Younger age, preoperative acidosis, emergency surgery, and intraoperative blood transfusion were independently associated with the occurrence of IHL.
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