Evidence map›Paper›PMID 42724140›Full record

ArticlePublic health ethics2026

Despair is Not Hopelessness: Autonomy and Behavioral Interventions for Deaths of Despair.

Alejandro Hortal, Jack M C Kwong

Abstract read
In one paragraph

Article in Public health ethics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alejandro HortalDepartment of Philosophy, Wake Forest University, Winston-Salem, NC, USA.ORCID https://orcid.org/0000-0001-6255-4488
Jack M C KwongAppalachian State University, Boone, NC, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The term 'deaths of despair' refers to suicide, drug overdoses, and alcohol-related mortality in the context of concern about rising mortality rates. This paper employs a philosophical distinction between despair and hopelessness, and their positive counterparts, hope and hopefulness, to examine how behavioral public policy can offer tools to reduce these deaths and what role autonomy plays in such contexts. The paper introduces a further distinction within hopelessness (desiderative and doxastic) each affecting autonomy in different ways, depending on whether desires, beliefs or both are compromised. The analysis considers autonomy from two perspectives: first, how it is diminished in the psychological and social contexts that give rise to deaths of despair; and second, how it may be further compromised by behavioral interventions that rely on paternalistic influence. By integrating these conceptual and ethical dimensions, the paper develops a framework for assessing when and how autonomy-sensitive behavioral interventions can be ethically justified in contexts marked by despair and hopelessness.

Identifiers

PMID42724140
PMCPMC13559188

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.