Evidence map›Paper›PMID 42724128›Full record

Observational studyNarra J2026

Real-world effectiveness of a topical dihydroavenanthramide D formulation for chronic pruritus: A multicenter clinical study with molecular evidence of pruritogenic pathway modulation.

Simone Ribero, Mario Vaccaro, Francesco Borgia, Carlo Mattozzi, Edoardo Zattra, Alessandra Mattiucci, Piercarlo Minoretti

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Narra J, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Simone RiberoSection of Dermatology, Department of Medical Sciences, University of Turin, Turin, Italy.
Mario VaccaroSection of Dermatology, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Francesco BorgiaSection of Dermatology, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Carlo MattozziPrivate Practice, Marsala, Italy.
Edoardo ZattraPrivate Practice, Bassano del Grappa, Italy.
Alessandra MattiucciPrivate Practice, Brescia, Italy.
Piercarlo MinorettiStudio Minoretti, Oggiono, Lecco, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic pruritus is a prevalent and clinically burdensome condition that substantially impairs quality of life and is sustained by complex interactions between neuro-immune signaling and epidermal barrier dysfunction. Central mediators implicated in this pruritogenic network include interleukin-4 (IL-4), interleukin-13 (IL-13), interleukin-31 (IL-31), substance P encoded by

Indexed as

PruritusAdministration, TopicalAdultAgedChronic DiseaseFemaleHumansInterleukin-13Interleukin-4MaleMiddle AgedNerve Growth FactorProspective StudiesSeverity of Illness IndexSubstance PTreatment OutcomeInterleukin-13Interleukin-4Nerve Growth FactorSubstance PChronic pruritusdihydroavenanthramide Dgene expressionnerve growth factorsubstance P

Identifiers

PMID42724128
PMCPMC13558874

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.