ArticleFrontiers in bioengineering and biotechnology2026
A preliminary feasibility study of a tough hydrogel as a nucleus pulposus substitute for degenerative disc disease.
Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Degenerative disc disease is characterized by low back pain caused by degeneration of the intervertebral discs. Hydrogels, with favorable biocompatibility and characteristics resembling the nucleus pulposus, have received attention as potential replacement materials. In this study, we developed a tough hydrogel with enhanced mechanical performance and conducted an initial assessment of its feasibility as a nucleus pulposus substitute. Methods: The hydrogel was fabricated by incorporating 2-hydroxyethyl methacrylate-treated silk fibers into the core of a polyvinyl alcohol hydrogel. Results and Discussion: The
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