Evidence map›Paper›PMID 42724057›Full record

ReviewFrontiers in artificial intelligence2026

Genealogies of organizational closure: from logical paradox to mind in life.

Sergio Rubin, Andrea Roli, Pasquale Stano, Luisa Damiano

Abstract readReview
In one paragraph

Review in Frontiers in artificial intelligence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sergio RubinResearch Center for Complex Systems (CRiSiCo), Department of Communication, Arts and Media, IULM University, Milan, Italy.
Andrea RoliDepartment of Computer Science and Engineering (Campus of Cesena), Università di Bologna, Cesena, Italy.
Pasquale StanoDepartment of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Lecce, Italy.
Luisa DamianoResearch Center for Complex Systems (CRiSiCo), Department of Communication, Arts and Media, IULM University, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organizational closure occupies a central position in contemporary theories of autonomy, anticipation, agency, sense making, and the continuity between life and mind. Its investigation has given rise to a diverse landscape of related explanations, including closure to information, cyclic closure, operational closure, semantic closure, closure-to-efficient causation, metabolic closure, and closure of constraints. Although each of these explanatory approaches captures important aspects of organizational closure, their proliferation has often generated conceptual ambiguity. As a result, organizational closure is frequently conflated with feedback loops, recursive algorithms, self-organization, or biochemical cycles. This paper develops a genealogical conceptual analysis of the research programs from which these various accounts emerged, tracing their origins across mathematical logic, first- and second-order cybernetics, general systems theory, thermodynamics, metabolic theory, relational biology, and the biology of cognition. In doing so, it provides a principled framework for assessing the commitments involved whenever a notion of closure is invoked, while clarifying the origins of these explanations and the relations among them. Particular attention is devoted to the roles of self-reference, circular causality, replication maps, semantics, free energy, automata, operations, and constraints in shaping the current understanding of organizational closure. On this basis, the study advances the interpretative thesis that organizational closure is most coherently understood as a circular organization of efficient causes through which living beings continuously produce and maintain the conditions of their own existence. From this perspective, organizational closure appears irreducible to purely algorithmic descriptions inherited from the Church-Turing thesis-not because living beings cannot be simulated in specific respects, but because the causal production of the conditions of their own realization cannot be exhaustively characterized as a state-determined syntactic procedure. This interpretation helps clarify the distinctions between organizational closure and the notions with which it is often conflated, while providing a framework for assessing current debates concerning artificial intelligence, large language models (LLMs), semantic meaning, and sense making in the face of ambiguity and logical paradox.

Indexed as

autopoiesisChurch thesisfabrication(M, R)-systemself-referenceturing machinevon Neumann self-reproducing automata

Identifiers

PMID42724057
PMCPMC13558211

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.