ArticleNarra J2026
Skin-mind connection in atopic dermatitis: Associations of disease severity with skin barrier function, stress, anxiety, and quality of life.
Article in Narra J, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Although skin barrier dysfunction and psychosocial impairment are well-recognized features of atopic dermatitis, the association remains incompletely understood. Evidence integrating objective measures of skin barrier function with stress, anxiety, quality of life, and disease severity is limited. Therefore, the aim of this study was to investigate the associations of disease severity with skin barrier function, psychological status, and quality of life in patients with atopic dermatitis. A hospital-based cross-sectional study was conducted at the Dermatology, Venereology, and Aesthetic Outpatient Clinic of Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia, in 2025. Adults aged ≥20 years with atopic dermatitis diagnosed according to the Hanifin-Rajka criteria were recruited consecutively. Disease severity was assessed using the Scoring Atopic Dermatitis (SCORAD) index. Skin barrier function was evaluated by measuring transepidermal water loss (TEWL) and stratum corneum hydration using a Tewameter and Corneometer, respectively. Anxiety, perceived stress, and quality of life were assessed using the Zung Self-Rating Anxiety Scale (SAS), Perceived Stress Scale (PSS), and Dermatology Life Quality Index (DLQI). Most patients were female (62.5%), and 68.8% had mild disease. Disease severity was not significantly associated with TEWL (
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