Evidence map›Paper›PMID 42724012›Full record

SynthesisFrontiers in immunology2026

Effect of daratumumab on patients with high-risk cytogenetic multiple myeloma: a systematic review and meta-analysis of randomized controlled trials.

Liang Su, Minlan Ye, Bowen Peng, Lei Fan, Jie Wu

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Liang Su *Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Minlan Ye *Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Bowen Peng *Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Lei FanGuang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Jie WuGuang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although daratumumab has been reported to significantly improve the prognosis of multiple myeloma (MM), its efficacy in patients with cytogenetically high-risk MM (HRMM) remains unclear. This meta-analysis aims to evaluate the effect of daratumumab on progression-free survival (PFS) and overall survival (OS) in patients with cytogenetically HRMM. Compared to treatment without daratumumab, treatment with daratumumab showed significant PFS (HR = 0.58, Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/, identifier CRD420251244272.

Indexed as

Antibodies, MonoclonalAntineoplastic AgentsMultiple MyelomaHumansRandomized Controlled Trials as TopicTreatment OutcomeAntibodies, MonoclonalAntineoplastic Agentsdaratumumabdaratumumabmeta-analysismultiple myelomarandomized controlled trialssystematic review

Identifiers

PMID42724012
PMCPMC13558208

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.