ArticleFrontiers in pediatrics2026
Association between serum phosphate levels and outcome among critically ill newborns: a retrospective cohort study.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: This study aimed to explore the relationship between serum phosphate levels and clinical outcomes in critically ill neonates. Methods: A retrospective cohort study was conducted using the Pediatric Intensive Care (PIC) database from (2010- 2018.) Multivariable regression models, generalized additive models, and threshold effect analysis were adopted to evaluate the relationship between serum phosphate levels within 24 h of ICU admission (Pi24) and neonatal outcomes. Results: A total of 1,902 critically ill neonates were enrolled. Pi24 was stratified into three tertile groups (Q1-Q3). Baseline characteristics and Kaplan-Meier curves showed that higher Pi24 correlated with higher 28-day mortality, peaking at 11% in the Q3 group. Multivariate Cox proportional hazards regression analysis revealed that, Q3 neonates had a 76% increased risk of 28-day mortality compared with Q1(HR = 1.76, 95%CI:1.08∼2.88, Conclusion: Elevated Pi24 levels were associated with increased risks of 28-day mortality and in-hospital death in critically ill neonates, while lower Pi24 levels independently predict prolonged hospital LOS Pi24 may represent a valuable prognostic biomarker for this population.
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