ArticleFrontiers in oncology2026
Quantitative MRI in the assessment of clival invasion in locally advanced nasopharyngeal carcinoma.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Objective: This study assesses the value of quantitative magnetic resonance imaging (qMRI) in evaluating clival invasion (CI) and monitoring therapeutic response in locally advanced nasopharyngeal carcinoma (LA-NPC). It also investigates the relationship between qMRI parameter changes in CI and regression of nasopharyngeal soft-tissue invasion. Methods: In this prospective study, fifty-five LA-NPC patients with CI from a single-center underwent qMRI at baseline (t0), pre-radiotherapy (t1), mid-radiotherapy (t2), and post-radiotherapy (t3). T1, T2, and T2* mappings were measured in manually delineated volumes of interest. Patients were categorized into complete response (CR) and non-CR groups based on nasopharyngeal soft tissue tumor regression per RECIST 1.1. The cervical vertebrae served as self-controls. Results: At baseline, T1, T2, and T2* mapping values were significantly higher in clival invasion than in normal cervical vertebrae ( Conclusions: The qMRI-derived T1, T2, and T2* mapping demonstrates potential utility in monitoring CI response in LA-NPC, serving as an inherently quantitative tool that warrants further investigation in larger cohorts.
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