Systemic inflammation, microbiology, and clinical outcomes in eosinophilic and non-eosinophilic acute exacerbations of chronic obstructive pulmonary disease.

Ning Zhang, Qiqiang Zhou, Sujie Zhao, Chen Zhang, Yahong Chen, Ying Liang, Yongchang Sun

Abstract read

In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ning Zhang *Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, China.

Qiqiang Zhou *Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, China.

Sujie Zhao *Department of Respiratory and Critical Care Medicine, Lulong County Hospital, Qinhuangdao, Hebei, China.

Chen ZhangInformation Management and Big Data Center, Peking University Third Hospital, Beijing, China.

Yahong ChenDepartment of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, China.

Ying LiangDepartment of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, China.

Yongchang SunDepartment of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Blood eosinophil (EOS) guides corticosteroid therapy in stable chronic obstructive pulmonary disease (COPD), but its prognostic value in COPD exacerbation (ECOPD) remains controversial. This study characterized clinical features and assessed the impact of EOS levels on clinical outcomes in hospitalized ECOPD patients. Methods: We retrospectively reviewed hospitalized patients with ECOPD between 2018 and 2023. Patients were categorized according to percentage of peripheral blood eosinophil: the eosinophilic group (EOS ≥ 2%) and the non-EOS group (EOS < 2%). The primary outcome was in-hospital mortality, while the secondary outcomes included ICU admission, mechanical ventilation, and length of hospital stay. Results: Among 511 patients (EOS group, Conclusion: Among hospitalized patients with ECOPD, elevated peripheral blood eosinophils were associated with favorable clinical outcomes, especially a reduced risk of ICU admission, as well as a lower systemic inflammation burden.

Indexed as

acute exacerbationchronic obstructive pulmonary diseaseeosinophilsprognosissystemic inflammation

Identifiers

PMID42723899

DOI10.3389/fmed.2026.1917271

PMCPMC13558021

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.