ArticleFrontiers in medicine2026
The double-edged role of SPAG6 in male reproductive toxicity: pro-invasive in leukemia, protective in germ cells.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Male testis is highly susceptible to irreversible damage from acute myeloid leukemia (AML) infiltration and subsequent chemotherapy. As a gene critical for sperm function, the role of SPAG6 in AML testicular infiltration and chemotherapy-induced injury remains poorly elucidated. Methods: SPAG6 expression was knocked down in C1498 leukemia cell line, and its impact on testicular infiltration was evaluated Results: Both AML infiltration and subsequent chemotherapy exerted profound damage on the testes. SPAG6 was highly expressed in normal mouse testes and was upregulated upon AML infiltration and chemotherapy. Knockdown of SPAG6 in leukemia cells was associated with suppressed proliferation and induced apoptosis Conclusion: SPAG6 may exert cell-type-specific, opposing roles in AML-infiltrated testes: SPAG6 depletion is associated with suppressed leukemic cell infiltration, potentially through modulation of cell adhesion, while its deficiency correlates with increased chemotherapy-induced injury to spermatogonial cells.
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