Evidence map›Paper›PMID 42723603›Full record

ArticleCirculation research2026

Obesity Increases Atherosclerosis Susceptibility via an Intertissue miR-30e-SLC7A11 Axis.

Chen Wang, Jianqing She, Xiaoli Qian, Haoyu Wu, Wenyang Hao, Xiao Liang, Ning Guo, Xulei Dai, Fangzhou He, Songyang He and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Chen Wang *Department of Cardiology (C.W., J.S., H.W., X.L., N.G., S.H., J.Z., Y. Lei, X.Z., H. Li, Y. Luo, S.G., X.Y., T.B., Y.X., Z.-Y.Y.), The First Affiliated Hospital of Xi'an Jiaotong University, China.
Jianqing She *Department of Cardiology (C.W., J.S., H.W., X.L., N.G., S.H., J.Z., Y. Lei, X.Z., H. Li, Y. Luo, S.G., X.Y., T.B., Y.X., Z.-Y.Y.), The First Affiliated Hospital of Xi'an Jiaotong University, China.
Xiaoli Qian *Cardiovascular Research Center, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, China (X.Q., W.H., F.H.).
Haoyu WuDepartment of Cardiology (C.W., J.S., H.W., X.L., N.G., S.H., J.Z., Y. Lei, X.Z., H. Li, Y. Luo, S.G., X.Y., T.B., Y.X., Z.-Y.Y.), The First Affiliated Hospital of Xi'an Jiaotong University, China.ORCID 0000-0001-9129-7150
Wenyang HaoCardiovascular Research Center, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, China (X.Q., W.H., F.H.).
Xiao LiangDepartment of Cardiology (C.W., J.S., H.W., X.L., N.G., S.H., J.Z., Y. Lei, X.Z., H. Li, Y. Luo, S.G., X.Y., T.B., Y.X., Z.-Y.Y.), The First Affiliated Hospital of Xi'an Jiaotong University, China.
Ning GuoDepartment of Cardiology (C.W., J.S., H.W., X.L., N.G., S.H., J.Z., Y. Lei, X.Z., H. Li, Y. Luo, S.G., X.Y., T.B., Y.X., Z.-Y.Y.), The First Affiliated Hospital of Xi'an Jiaotong University, China.
Xulei DaiDepartment of Laboratory Animal Science, School of Basic Medical Sciences, Xi'an Jiaotong University, China (X.D.).ORCID 0009-0003-2475-2442
Fangzhou HeCardiovascular Research Center, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, China (X.Q., W.H., F.H.).ORCID 0000-0002-6853-6544
Songyang HeDepartment of Cardiology (C.W., J.S., H.W., X.L., N.G., S.H., J.Z., Y. Lei, X.Z., H. Li, Y. Luo, S.G., X.Y., T.B., Y.X., Z.-Y.Y.), The First Affiliated Hospital of Xi'an Jiaotong University, China.
Jin ZhangDepartment of Cardiology (C.W., J.S., H.W., X.L., N.G., S.H., J.Z., Y. Lei, X.Z., H. Li, Y. Luo, S.G., X.Y., T.B., Y.X., Z.-Y.Y.), The First Affiliated Hospital of Xi'an Jiaotong University, China.ORCID 0000-0001-6399-0513
Yuyang LeiDepartment of Cardiology (C.W., J.S., H.W., X.L., N.G., S.H., J.Z., Y. Lei, X.Z., H. Li, Y. Luo, S.G., X.Y., T.B., Y.X., Z.-Y.Y.), The First Affiliated Hospital of Xi'an Jiaotong University, China.ORCID 0009-0006-0211-9330
Xiaozhen ZhuoDepartment of Cardiology (C.W., J.S., H.W., X.L., N.G., S.H., J.Z., Y. Lei, X.Z., H. Li, Y. Luo, S.G., X.Y., T.B., Y.X., Z.-Y.Y.), The First Affiliated Hospital of Xi'an Jiaotong University, China.
Hongbing LiDepartment of Cardiology (C.W., J.S., H.W., X.L., N.G., S.H., J.Z., Y. Lei, X.Z., H. Li, Y. Luo, S.G., X.Y., T.B., Y.X., Z.-Y.Y.), The First Affiliated Hospital of Xi'an Jiaotong University, China.
Yongbai LuoDepartment of Cardiology (C.W., J.S., H.W., X.L., N.G., S.H., J.Z., Y. Lei, X.Z., H. Li, Y. Luo, S.G., X.Y., T.B., Y.X., Z.-Y.Y.), The First Affiliated Hospital of Xi'an Jiaotong University, China.ORCID 0000-0001-8857-5893
Kai DengDepartment of Clinical Laboratory (K.D., Y. Liu), The First Affiliated Hospital of Xi'an Jiaotong University, China.
Yi LiuDepartment of Clinical Laboratory (K.D., Y. Liu), The First Affiliated Hospital of Xi'an Jiaotong University, China.
Shanshan GaoDepartment of Cardiology (C.W., J.S., H.W., X.L., N.G., S.H., J.Z., Y. Lei, X.Z., H. Li, Y. Luo, S.G., X.Y., T.B., Y.X., Z.-Y.Y.), The First Affiliated Hospital of Xi'an Jiaotong University, China.ORCID 0000-0002-4111-0535
Xiao YuanDepartment of Cardiology (C.W., J.S., H.W., X.L., N.G., S.H., J.Z., Y. Lei, X.Z., H. Li, Y. Luo, S.G., X.Y., T.B., Y.X., Z.-Y.Y.), The First Affiliated Hospital of Xi'an Jiaotong University, China.
Hui LiuBioBank, The First Affiliated Hospital of Xi'an Jiaotong University, China (H. Liu).ORCID 0000-0002-0372-9492
Ting BaiDepartment of Cardiology (C.W., J.S., H.W., X.L., N.G., S.H., J.Z., Y. Lei, X.Z., H. Li, Y. Luo, S.G., X.Y., T.B., Y.X., Z.-Y.Y.), The First Affiliated Hospital of Xi'an Jiaotong University, China.
Ying XiongDepartment of Cardiology (C.W., J.S., H.W., X.L., N.G., S.H., J.Z., Y. Lei, X.Z., H. Li, Y. Luo, S.G., X.Y., T.B., Y.X., Z.-Y.Y.), The First Affiliated Hospital of Xi'an Jiaotong University, China.
John Y-J ShyyDivision of Cardiology, Department of Medicine, University of California, San Diego, La Jolla (J.Y.-J.S.).ORCID 0000-0002-5625-753X
Zu-Yi YuanDepartment of Cardiology (C.W., J.S., H.W., X.L., N.G., S.H., J.Z., Y. Lei, X.Z., H. Li, Y. Luo, S.G., X.Y., T.B., Y.X., Z.-Y.Y.), The First Affiliated Hospital of Xi'an Jiaotong University, China.ORCID 0000-0002-7341-6889

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWith obesity as a risk factor for atherosclerotic disease, recent research suggests that adipose tissue in obese animal models and humans can generate endocrine-like molecules that affect arterial health. Previous studies showed that microRNA-30e (miR-30e) levels are elevated in atherosclerosis and solute carrier family 7 member 11 (SLC7A11), a cystine/glutamate transporter, is involved in atherogenesis. However, whether an endocrine-like link between the adipose-derived miR-30e-5p and SLC7A11 in the vascular endothelium can lead to obesity-caused atherosclerosis is unknown.

methodsmiRNA data mining and reverse transcription-polymerase chain reaction validations were used to demonstrate the positive association among serum levels of miR-30e-5p, obesity, and coronary arterial disease in human patients. Transcriptomics (bulk RNA sequencing and single-nucleus RNA sequencing), metabolomics, and in silico analysis were used to establish a miR-30e-5p-SLC7A11 regulation of central carbon metabolism, mitochondrial and endothelial cell (EC) function. Mouse models with EC-specific

resultsThe level of adipocyte-derived miR-30e-5p was significantly upregulated in obese human patients with coronary artery disease and in obese and atherosclerotic mice. Mediated through serum exosomes, the adipocyte-generated miR-30e-5p targeted

conclusionsOur multiomics approaches demonstrate that the adipose-derived miR-30e-5p downregulated

Indexed as

Amino Acid Transport Systems, BasicAmino Acid Transport System y+AtherosclerosisMicroRNAsObesityAnimalsEndothelial CellsFemaleHumansMaleMiceMice, Inbred C57BLMice, KnockoutAmino Acid Transport Systems, BasicAmino Acid Transport System y+MicroRNAsMIRN30b microRNA, humanMirn30d microRNA, mouseSLC7A11 protein, humanSlc7a11 protein, mouseatherosclerosisendothelial cellexosomesmicroRNAsobesityvascular diseases

Identifiers

PMID42723603
PMCPMC13649275

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.