Evidence map›Paper›PMID 42723477›Full record

ReviewCardiovascular therapeutics2026

FTH1 mRNA-Protein Discordance in Cardiac Ferroptosis: Multilayer Posttranscriptional and Degradative Control.

Feng Zhou, Jia-Bin Zhou, Yi-Qing Yan, Tian-Peng Wei, Dan Wu, Yi-Fan Yang, Ru-Xing Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cardiovascular therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Feng ZhouDepartment of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi Medical Center, Nanjing Medical University, Wuxi, China, njmu.edu.cn.ORCID https://orcid.org/0009-0007-3964-0303
Jia-Bin ZhouDepartment of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi Medical Center, Nanjing Medical University, Wuxi, China, njmu.edu.cn.ORCID https://orcid.org/0009-0009-0927-8109
Yi-Qing YanDepartment of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi Medical Center, Nanjing Medical University, Wuxi, China, njmu.edu.cn.ORCID https://orcid.org/0009-0006-2516-7634
Tian-Peng WeiDepartment of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi Medical Center, Nanjing Medical University, Wuxi, China, njmu.edu.cn.ORCID https://orcid.org/0009-0007-8068-1473
Dan WuDepartment of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi Medical Center, Nanjing Medical University, Wuxi, China, njmu.edu.cn.
Yi-Fan YangDepartment of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi Medical Center, Nanjing Medical University, Wuxi, China, njmu.edu.cn.ORCID https://orcid.org/0009-0006-6989-7823
Ru-Xing WangDepartment of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi Medical Center, Nanjing Medical University, Wuxi, China, njmu.edu.cn.ORCID https://orcid.org/0000-0001-7355-5048

Funding

National Natural Science Foundation of China 82370342Natural Science Foundation of Jiangsu Province BK20231145
6 · The paper itself

Abstract

Ferritin heavy Chain 1 (FTH1) is a key protective factor against ferroptosis in the heart, yet its protein abundance can diverge from transcript levels in cardiac ferroptosis contexts. Since resistance to ferroptosis depends on FTH1 protein abundance rather than transcript levels and its ferroxidase activity cannot be readily compensated by other ferritin subunits, this mismatch is functionally consequential. This review organizes the evidence into three regulatory layers acting downstream of transcription. Iron regulatory protein/iron-responsive element (IRP/IRE) signaling gates ribosome recruitment at the 5

Indexed as

FerritinsFerroptosisHeart DiseasesMyocytes, CardiacOxidoreductasesRNA, MessengerRNA Processing, Post-TranscriptionalAnimalsEpitranscriptomeHumansIronNuclear Receptor CoactivatorsProteolysisRNA StabilitySignal TransductionFerritinsFTH1 protein, humanIronNCOA4 protein, humanNuclear Receptor CoactivatorsOxidoreductasesRNA, Messengercardiac ferroptosisferritinophagyFTH1iron homeostasisIRP/IREposttranscriptional regulation

Identifiers

PMID42723477
PMCPMC13563059

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.