Observational studyAnnals of medicine2026
Association of AI-derived abdominal organ volumetry with postoperative outcomes in clear cell renal cell carcinoma: a multicentre study.
Observational study in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
backgroundCT-derived body composition parameters are associated with clinical outcomes in clear cell renal cell carcinoma (ccRCC), but the prognostic value of abdominal solid organ volumes remains unclear.
methodsIn this multicentre study, 1,720 patients with ccRCC who underwent nephrectomy across four centres and 3,052 healthy controls were included. A deep learning algorithm was used to automatically quantify abdominal organ volumes. Organ volume indices were calculated by normalizing volumes to body surface area. Associations between abdominal organ volumes and recurrence-free survival (RFS) and overall survival (OS) were evaluated using centre-stratified Cox regression models. Multivariable models were adjusted for age, gender, tumour size, laterality, surgical approach, pT stage, pN stage, International Society of Urological Pathology grade and tumor necrosis.
resultsDuring a median follow-up of 51.6 (49.2-52.8) months, 165 patients experienced recurrence and 95 died. Organ volume distributions were similar across centres. Compared with healthy controls, ccRCC patients showed higher spleen and adrenal gland volume indices and lower pancreatic volume index. In multivariable Cox analyses, higher liver volume (HR = 1.42,
conclusionsHigher liver and right adrenal gland volumes were associated with worse OS in ccRCC. These findings warrant external validation and further mechanistic investigation.
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