Evidence map›Paper›PMID 42723354›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2026

Exploring novel isatin derivatives as SARS-CoV-2 3CL

Jian Song, Cai Shi, Boning Yang, Jingxiang Yang, Caifei Huang, Jiaqi Liu, Shuwen Wu, Shuyuan Mo, Jian Yang

Abstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jian SongDepartment of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, China.
Cai ShiDepartment of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, China.
Boning YangDepartment of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, China.
Jingxiang YangDepartment of Pharmacy, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
Caifei HuangDepartment of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, China.
Jiaqi LiuDepartment of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, China.
Shuwen WuThe College of Life Sciences, State Key Laboratory of Virology, Modern Virology Research Center, Wuhan University, Wuhan, China.
Shuyuan MoDepartment of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, China.
Jian YangDepartment of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of novel isatin derivatives were synthesised by incorporating phenyl, biphenyl, naphthyl and indolyl moieties into the N-1 position and screened in vitro against SARS-CoV-2 3CL

Indexed as

Antiviral AgentsBetacoronavirusCoronavirus 3C ProteasesIsatinSARS-CoV-2Dose-Response Relationship, DrugHumansMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAntiviral AgentsCoronavirus 3C ProteasesIsatinisatin derivativesmolecular dockingmolecular dynamicsSARS-CoV-2 3CLpro inhibitors

Identifiers

PMID42723354
PMCPMC13573511

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.