ArticleThe clinical respiratory journal2026
Venous Thromboembolism in Severe Community-Acquired Pneumonia at High-Altitude Areas: Prevalence, Risk and Outcome.
Article in The clinical respiratory journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionHigh-altitude exposure and hypoxia may induce a hypercoagulable state, thereby promoting the development of venous thromboembolism (VTE). Few studies have reported the incidence of VTE among patients with severe community-acquired pneumonia (SCAP) in high-altitude regions. We conducted a study to investigate the prevalence, risk factors, prognosis, and potential thromboprophylaxis strategies of VTE in this patient population.
methodsWe prospectively enrolled 158 adult patients with SCAP admitted to Lhasa People's Hospital between January 1, 2023, and December 31, 2024. All patients underwent lower extremity venous compression ultrasound and/or computed tomography pulmonary angiography examination. Clinical characteristics, including demographic information, medical history, vital signs, laboratory findings, treatments, complications, and clinical outcomes, were compared for patients with and without VTE in these two subgroups.
resultsOf the 158 patients, 74 (46.8%) developed VTE, including 68 with DVT, 21 with pulmonary embolism (PE) and 15 with both DVT and PE. A total of 123 (77.8%) patients received VTE prophylaxis, and there was no significant difference in the incidence of VTE among the groups with different prophylactic measures (p = 0.838). Multivariate logistic regression analysis showed an association between lower partial pressure of arterial oxygen (PaO
conclusionsThe prevalence of VTE is unexpectedly high in hospitalized patients with SCAP in high-altitude regions and may be associated with a poor prognosis. Early identification of patients at high risk for VTE and optimization of thromboprophylactic strategies are therefore warranted improve patient outcomes.
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