Evidence map›Paper›PMID 42723205›Full record

Trial reportLiver international : official journal of the International Association for the Study of the Liver2026

A 7-mm Covered TIPS Reduces Hepatic Encephalopathy Without Increasing Rebleeding in Cirrhotic Patients With Small Liver: A Randomized Study.

Fuquan Liu, Kan Zhang, Yu Zhang, Quanwei He, Mingming Meng, Xuemei Ma, Bing Zhu, Yifan Wu, Linjing An, Yifan Lv and 8 more

Registry-linked trialAbstract readClinical Trial, Phase IMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Liver international : official journal of the International Association for the Study of the Liver, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02541825 (Using Covered Stent of Diameter of 7mm in a Prospective, Single Blind, Randomized, Controlled Study of TIPS), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02541825 phase1unknown statusnot on this map

Using Covered Stent of Diameter of 7mm in a Prospective, Single Blind, Randomized, Controlled Study of TIPS(Transjugular Intrahepatic Portosystemic Stent Shunt )

TypeinterventionalSponsorBeijing Shijitan Hospital, Capital Medical UniversityRan2015 to 2017Enrolled216ConditionsLiver DiseaseArmsthe stent of diameter of 7mm, the stent of diameter of 8mm
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A 7-mm Covered TIPS Reduces Hepatic Encephalopathy Without Increasing Rebleeding in Cirrhotic Patients With Small Liver: A Randomized Study.Liver international : official journal of the International Association for the Study of the Liver · 2026
    Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Fuquan LiuLiver Disease Center, Hainan Hospital of Chinese PLA General Hospital, Sanya, China.ORCID https://orcid.org/0000-0003-1972-7712
Kan ZhangPulmonary and Critical Medicine, The 8th Medical Center of Chinese PLA General Hospital, Beijing, China.ORCID https://orcid.org/0009-0007-5736-9529
Yu ZhangDepartment of Gastroenterology and Interventional Therapy, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Quanwei HeLiver Disease Center, Hainan Hospital of Chinese PLA General Hospital, Sanya, China.ORCID https://orcid.org/0009-0003-2134-4814
Mingming MengDepartment of Gastroenterology and Interventional Therapy, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0003-3560-1052
Xuemei MaInterventional Therapy, The Fifth Medical of Chinese PLA General Hospital, Beijing, China.
Bing ZhuInterventional Therapy, The Fifth Medical of Chinese PLA General Hospital, Beijing, China.
Yifan WuDepartment of Gastroenterology and Interventional Therapy, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0009-0004-2642-7245
Linjing AnInterventional Therapy, The Fifth Medical of Chinese PLA General Hospital, Beijing, China.
Yifan LvDepartment of Gastroenterology and Interventional Therapy, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Fuhuang LinDepartment of Interventional Therapy, Hainan Provincial People's Hospital, Haikou, China.
Ke ZhangDepartment of General Surgery, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Bowen LiuDepartment of Gastroenterology and Interventional Therapy, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0001-8837-7870
Xiujuan ChangInterventional Therapy, The Fifth Medical of Chinese PLA General Hospital, Beijing, China.ORCID https://orcid.org/0000-0002-4961-8560
Huiguo DingCenter for Hepatology and Gastroenterology, Beijing You-An Hospital, Capital Medical University, Beijing, China.
Jiangtao LiuLiver Disease Center, Hainan Hospital of Chinese PLA General Hospital, Sanya, China.ORCID https://orcid.org/0000-0003-4506-6102
Yan ChenInterventional Therapy, The Fifth Medical of Chinese PLA General Hospital, Beijing, China.
Yongping YangLiver Disease Center, Hainan Hospital of Chinese PLA General Hospital, Sanya, China.ORCID https://orcid.org/0000-0002-8307-1095

Funding

Natural Science Foundation of Hainan Province 822MS195Research and Translational Application of Clinical Characteristic Diagnosis and Treatment Technology in the Capital Z221100007422002the State Key Projects Specialized on Infectious Disease, Chinese Ministry of Science and Technology 2018ZX10725506
6 · The paper itself

Abstract

BACKGROUND/

aimsInternational guidelines recommend initiating transjugular intrahepatic portosystemic shunt (TIPS) placement with an 8-mm stent. However, there is an evident lack of randomized controlled trials evaluating TIPS diameters < 8 mm in cirrhotic patients with a relatively small liver. The aim of this study was to determine whether 7 mm-covered TIPS, compared with 8-mm stents, could achieve comparable shunt function with a lower incidence of hepatic encephalopathy (HE).

methodsIn this multicenter randomized controlled trial, patients with cirrhosis and relatively small liver were randomized 1:1 to receive TIPS with a 7-mm (n = 92) or 8-mm (n = 92) covered stent to prevent variceal rebleeding. The primary endpoint was the incidence of overt HE after randomization. All-cause rebleeding, orthotopic liver transplantation (OLT)-free survival and a composite of these outcomes, were designated as secondary endpoints.

resultsAmong the 184 enrolled patients, the predominant etiologies of liver cirrhosis were hepatitis B virus infection (56.0%) and alcohol-related liver disease (20.7%). Over a median follow-up of 26.5 months, overt HE occurred in 19 patients (20.7%) in the 7-mm group and 33 patients (35.9%) in the 8-mm group. The 2-year cumulative incidence of overt HE was significantly lower in the 7-mm group than in the 8-mm group (21.4% vs. 37.2%, p = 0.02). Stent diameter, post-TIPS portosystemic pressure gradient, pre-covert HE and MELD-Na score were identified as independent risk factors for overt HE. The rates of shunt dysfunction were statistically similar between groups (8.7% vs. 8.7%, p = 1.0), as were 2-year rebleeding rates (10.9% vs. 9.8%, p = 0.81) and OLT-free survival rates (91.3% vs. 88.0%, p = 0.82).

conclusionsA 7-mm covered TIPS demonstrated comparable shunt function to an 8-mm covered stents, with a significantly lower risk of overt HE. These findings support consideration of 7-mm TIPS stents for preventing variceal rebleeding in cirrhotic patients with a small liver who are undergoing TIPS. TRAIL REGISTRATION: ClinicalTrials.gov, NCT02541825.

Indexed as

Esophageal and Gastric VaricesGastrointestinal HemorrhageHepatic EncephalopathyLiverLiver CirrhosisPortasystemic Shunt, Transjugular IntrahepaticStentsAgedFemaleHumansLiver TransplantationMaleMiddle AgedRecurrenceTreatment Outcomehepatic encephalopathyliver cirrhosisstent diametertransjugular intrahepatic portosystemic shuntvariceal rebleeding

Identifiers

PMID42723205
PMCPMC13562823

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.