Trial reportBMC psychology2026
Neural correlates of response inhibition following cognitive behavioral therapy in obsessive-compulsive disorder: a randomized controlled EEG study.
Trial report in BMC psychology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07000812 (Neurophysiological Effects of Cognitive Behavioral Therapy in the Treatment of Obsessive-Compulsive Disorder), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Neurophysiological Effects of Cognitive Behavioral Therapy in the Treatment of Obsessive-Compulsive Disorder: An EEG Clinical Study
Who cites it
0 citing papers in PubMed.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCognitive behavioral therapy (CBT) with exposure and response prevention is an established treatment for obsessive-compulsive disorder (OCD), yet the electrophysiological indices through which symptom improvement occurs remain incompletely understood. Response inhibition deficits have been implicated in OCD and may represent a key neurocognitive target of treatment. The present randomized controlled trial (Clinicaltrials.gov registiration no: NCT07000812) examined whether CBT is associated with changes in behavioral and electrophysiological indices of response inhibition.
methodsSixty adults meeting DSM-5 criteria for OCD were randomized to a 12-week CBT program (n = 30) or a waitlist control condition (n = 30). Clinical severity was assessed using the Yale-Brown Obsessive Compulsive Scale (Y-BOCS), alongside measures of obsessive beliefs and intolerance of uncertainty. Response inhibition was evaluated using a Go/No-Go task while electroencephalography was recorded. Mean No-Go P3 amplitude (300-600 ms) at frontocentral regions of interest served as the primary neural outcome. Assessments were conducted at baseline and post-treatment.
resultsRelative to the waitlist group, participants receiving CBT showed a significant reduction in OCD symptom severity, accompanied by improvements in obsessive beliefs and intolerance of uncertainty. Behavioral performance indicated a reduction in commission errors on No-Go trials following CBT. Electrophysiologically, a significant Group × Time interaction was observed for No-Go P3 amplitude, reflecting an increase from pre- to post-treatment in the CBT group, with no meaningful change in the waitlist group. No baseline differences were observed between groups.
conclusionsCBT for OCD was associated with both clinical improvement and enhanced neural indices of response inhibition, as reflected by increased No-Go P3 amplitude. These findings suggest that therapeutic change in OCD may involve increased engagement of electrophysiological indices supporting response inhibition. Integrating electrophysiological measures with clinical outcomes may help clarify the neurocognitive processes underlying effective psychological interventions.
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