Evidence map›Paper›PMID 42723116›Full record

Observational studyAntimicrobial resistance and infection control2026

Potential of plasma metagenomic next-generation sequencing to guide antibiotic therapy in acute necrotizing pancreatitis with early fever: a prospective multicenter cohort study.

Xiaoyue Hong, Dingcheng Shen, Chiayen Lin, Xintong Cao, Zefang Sun, Baiqi Liu, Rong Guo, Zhiyong Liu, Tao Luo, Yi Yu and 4 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Antimicrobial resistance and infection control, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Xiaoyue Hong *Division of Pancreatic Surgery, Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, China.
Dingcheng Shen *Division of Pancreatic Surgery, Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, China.
Chiayen LinDivision of Pancreatic Surgery, Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, China.
Xintong CaoDivision of Pancreatic Surgery, Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, China.
Zefang SunDivision of Pancreatic Surgery, Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, China.
Baiqi LiuDivision of Pancreatic Surgery, Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, China.
Rong GuoDivision of Pancreatic Surgery, Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, China.
Zhiyong LiuDepartment of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, China.
Tao LuoDepartment of General Surgery, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, Hunan Province, 415000, China.
Yi YuDepartment of General Surgery, The First People's Hospital of Chenzhou City, Chenzhou, Hunan Province, 423000, China.
Ming YangDepartment of General Surgery, Liuyang People's Hospital, Changsha, Hunan Province, 410300, China.
Bin FengDepartment of Hepatobiliary and Pancreatic Surgery, Medical Center of Digestive Disease, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan Province, 412000, China.
Wenqian ZhangBGI Genomics, Shenzhen, 518083, China.
Gengwen HuangDivision of Pancreatic Surgery, Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, China. huanggengwen@csu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIndiscriminate antibiotic use remains common in febrile patients with acute necrotizing pancreatitis (ANP), particularly during the early phase. Metagenomic next‑generation sequencing (mNGS) has shown diagnostic utility for infected pancreatic necrosis (IPN) and may offer a means to guide antimicrobial therapy. We aimed to explore whether mNGS could potentially improve the appropriateness of antibiotic use in ANP patients presenting with early fever.

methodsThis prospective multicenter cohort study was conducted at five hospitals in China, enrolling ANP patients who developed fever within two weeks of symptom onset. Antibiotic susceptibility was defined per local microbiology laboratory reports. The hypothetical impact of mNGS on reducing inappropriate antibiotic use was evaluated through a retrospective simulation using predefined criteria from the BGI China antimicrobial drug usage card, as mNGS results were not disclosed to the treating teams during the actual clinical course.

resultsBetween May 2023 and December 2024, 125 ANP patients with early fever were enrolled. Antibiotics were administered to 91.2% (114/125) of patients, whereas only 23.2% (29/125)were eventually confirmed to have IPN, and the rate of appropriate antibiotic use was 14.5% (17/117) based on conventional culture. In our simulated model, if therapy had been guided by plasma mNGS results, the estimated rate of appropriate antibiotic use could have increased to 71.8%.

conclusionsPlasma mNGS facilitates rapid pathogen identification and shows potential for improving antibiotic appropriateness in ANP patients with early fever.

Indexed as

Anti-Bacterial AgentsFeverHigh-Throughput Nucleotide SequencingMetagenomicsPancreatitis, Acute NecrotizingAdultAgedChinaFemaleHumansMaleMiddle AgedProspective StudiesAnti-Bacterial AgentsAcute necrotizing pancreatitisAntibiotic stewardshipInfected pancreatic necrosisMetagenomic next-generation sequencing

Identifiers

PMID42723116
PMCPMC13563972

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.