ArticleNature metabolism2026
ALKBH5 activates creatine-driven thermogenesis by stabilizing CKB mRNA in response to cold.
Yinliang Zhang, Chunyuan Du, Wei Qiao, Ping Qiu, Chaofan Xu, Xiaohan Yang, Jingran Hao, Dong Zhao, Xiaochen Gai, Yongsheng Chang
Abstract read
In one paragraphArticle in Nature metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Yinliang Zhang *Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Key Laboratory of Cellular Homeostasis and Disease, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China. zhangyinliang@tmu.edu.cn.ORCID http://orcid.org/0000-0002-1772-6073 Chunyuan Du *Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Key Laboratory of Cellular Homeostasis and Disease, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Wei Qiao *Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Key Laboratory of Cellular Homeostasis and Disease, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Ping Qiu *Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Key Laboratory of Cellular Homeostasis and Disease, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Chaofan XuKey Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Key Laboratory of Cellular Homeostasis and Disease, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Xiaohan YangDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Jingran HaoKey Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Key Laboratory of Cellular Homeostasis and Disease, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Yongsheng ChangKey Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Key Laboratory of Cellular Homeostasis and Disease, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China. changys@tmu.edu.cn.ORCID http://orcid.org/0000-0002-7846-8127 Funding
National Natural Science Foundation of China (National Science Foundation of China) 82230027National Natural Science Foundation of China (National Science Foundation of China) 82300953
6 · The paper itselfAbstract
Non-shivering thermogenesis contributes to increased energy expenditure and can be a potential therapy to combat obesity. Here we show that the adipose tissue N
Indexed as
AlkB Homolog 5, RNA DemethylaseCold TemperatureCreatineRNA, MessengerThermogenesisAnimalsEnergy MetabolismFemaleHumansMaleMiceMice, Inbred C57BLMice, KnockoutObesityRNA StabilityUncoupling Protein 1ALKBH5 protein, mouseAlkB Homolog 5, RNA DemethylaseCreatineRNA, MessengerUncoupling Protein 1
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