Evidence map›Paper›PMID 42722783›Full record

ArticleMolecular imaging and biology2026

Macrocycle Chelator Conjugation on the C3 Hydroxyl Group of 17β-Estradiol reduces Estrogen Receptor Binding.

Pierre Cheung, Mallesh Pandrala, Abraham Moses, Madeleine Landry, Craig S Levin, Corinne Beinat

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Article in Molecular imaging and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pierre CheungDepartment of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University School of Medicine, 650-725-3113; 1701 Page Mill Road, Stanford, CA, 94304, USA.
Mallesh PandralaDepartment of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University School of Medicine, 650-725-3113; 1701 Page Mill Road, Stanford, CA, 94304, USA.
Abraham MosesDepartment of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University School of Medicine, 650-725-3113; 1701 Page Mill Road, Stanford, CA, 94304, USA.
Madeleine LandryDepartment of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University School of Medicine, 650-725-3113; 1701 Page Mill Road, Stanford, CA, 94304, USA.
Craig S LevinDepartment of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University School of Medicine, 650-725-3113; 1701 Page Mill Road, Stanford, CA, 94304, USA.
Corinne BeinatDepartment of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University School of Medicine, 650-725-3113; 1701 Page Mill Road, Stanford, CA, 94304, USA. cbeinat@stanford.edu.ORCID http://orcid.org/0000-0003-1718-3272

Funding

Society of Nuclear Medicine and Molecular Imaging - Mars Shot Mars Shot Award
6 · The paper itself

Abstract

purposeTumor heterogeneity in breast cancer complicates accurate molecular characterization when using standard-of-care imaging modalities. In this study, gallium-68 labeled estradiol-derivatives were synthesized and evaluated as candidate tracers to be used for multiplexed PET imaging with the goal of improving the molecular characterization of breast cancer. PROCEDURES: 17β-estradiol was conjugated to DOTA and NODAGA macrocycles and radiolabeled with gallium-68. The selectivity of the resulting radiotracers, [

resultsBoth radiotracers were obtained with high radiochemical purity. Neither [

conclusionTwo estradiol-derived radiotracers were successfully synthesized and tested, however neither showed selective binding towards ER in vitro or in vivo. The conjugation site of the cyclic macrocycle on 17β-estradiol is likely a key parameter to retain strong binding towards ER. These findings identify an important limitation for chelator-based ER tracer design.

Indexed as

Breast cancerEstradiolMultiplexed PETPET imaging

Identifiers

PMID42722783

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.