ArticleJournal of perinatology : official journal of the California Perinatal Association2026
Magnesium therapy in persistent pulmonary hypertension of the newborn: a scoping review.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
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Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo map evidence on magnesium sulfate (MgSO₄) therapy for PPHN, focusing on efficacy, safety, mechanisms, and knowledge gaps. STUDY
designScoping review following JBI methodology and PRISMA-ScR. MEDLINE, Embase, Cochrane Reviews, and CENTRAL were searched without date restrictions.
resultsThirteen publications were included: 11 primary clinical reports, including three randomized trials, and two evidence syntheses. The primary reports included 253 neonates but differed in populations, severity, comparators, and outcomes. Intravenous MgSO₄ usually comprised a 200 mg/kg loading dose followed by continuous infusion. Small, mostly uncontrolled studies reported improved oxygenation but could not establish efficacy. Comparative studies showed slower or less consistent responses than inhaled nitric oxide or sildenafil. Adverse effects included hypotension, bradycardia, and increased inotropic requirements; long-term safety data were limited.
conclusionEvidence remains insufficient to support routine MgSO₄ use for PPHN.
Identifiers
42722769What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.