SynthesisChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2026
Spontaneous complete regression of congenital brain tumors - a systematic literature review and case report.
Synthesis in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Spontaneous complete regression of congenital brain tumors - a systematic literature review and case report.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Pooled it
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe study aimed to review the available literature on spontaneous complete regression of congenital brain tumors and report an institutional case with a posterior fossa tumor that involuted at the age of 3 months.
methodsA systematic review was conducted in accordance with PRISMA guidelines. The study protocol was registered with INPLASY. A systematic review of the articles published from inception to 5 April 2026 in Web of Science, Scopus, PubMed (MEDLINE), and Embase was conducted. Six eligible case reports were identified and included in the analysis.
resultsInitial clinical presentation varied, with neurological deficits observed in 2/7 patients, signs of intracranial hypertension in 4/7 patients, and no neurological symptoms in one neonate. Tumors were most commonly located within deep brain structures (3/7), followed by cortical regions (2/7) and extracerebral locations (1/7). Histopathological grading revealed high-grade tumors in 3/7 patients and low-grade tumors in 2/7 individuals. Tumor resection was not pursued because of risky tumor topography (2/7), presumed benign tumor biology with a wait-and-see strategy (1/7), or parental decision to pursue hospice care (1/7). In three individuals, tumor surgery had been initially planned after gaining a greater body weight. Complete spontaneous regression was achieved between 3 and 33 months of age.
conclusionSpontaneous complete regression of congenital brain tumors is a rare and incompletely understood phenomenon. Our study highlights the heterogeneity of histopathological findings, lesion localization, and the subtle clinical presentation in this age group.
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