A novel multi-aptamer electrospun nanofibrous membrane for simultaneous selective extraction of monoamine neurotransmitters and determination in biological samples by LC-MS.

Xijia Zhang, Junfeng Qin, Chen Ma, Ningning Wang, Yufeng Li, Juanjuan Zhao, Dongsheng Li

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Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Xijia ZhangSchool of Pharmacy, Shandong Medical and Pharmaceutical University, No. 318, Gangcheng East Street, Laishan District, Yantai City, Shandong Province, 264003, PR China.

Junfeng QinDepartment of Psychological Clinic, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao, Shandong Province, 266071, PR China.

Chen MaSchool of Pharmacy, Shandong Medical and Pharmaceutical University, No. 318, Gangcheng East Street, Laishan District, Yantai City, Shandong Province, 264003, PR China.

Ningning WangSchool of Pharmacy, Shandong Medical and Pharmaceutical University, No. 318, Gangcheng East Street, Laishan District, Yantai City, Shandong Province, 264003, PR China.

Yufeng LiDepartment of Psychological Clinic, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao, Shandong Province, 266071, PR China. lyfzju2024@163.com.

Juanjuan ZhaoSchool of Pharmacy, Shandong Medical and Pharmaceutical University, No. 318, Gangcheng East Street, Laishan District, Yantai City, Shandong Province, 264003, PR China. zhaojuanjuan@sdmpu.edu.cn.

Dongsheng LiSchool of Pharmacy, Shandong Medical and Pharmaceutical University, No. 318, Gangcheng East Street, Laishan District, Yantai City, Shandong Province, 264003, PR China. lidongsheng2007@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dopamine (DA) and serotonin (5-HT) are key monoamine neurotransmitters, the sensitive determination of which in biological matrices is challenging owing to low concentrations and strong matrix interference. In this study, a multi-aptamer-functionalized electrospun membrane (MA-Au@PVP/PVDF) was developed by simultaneously immobilizing the DA aptamer (Apt-DA) and the 5-HT aptamer (Apt-5-HT) on the membrane surface via Au-S bonds. The membrane combines high specific surface area, good stability, and aptamer-based specificity, enabling simultaneous and selective extraction of DA and 5-HT from complex samples. The enriched analytes were subsequently quantified using liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS). The maximum adsorption capacities of the MA-Au@PVP/PVDF membrane were 190.8 ng/cm

Indexed as

Biological sample pretreatmentElectrospun membraneLC-Q-TOF-MSMonoamine neurotransmittersMulti-aptamerSelective extraction

Identifiers

PMID42722748

DOI10.1021/jasms.3c00326

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